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Education
B.S. Biology, summa cum laude, College of William and Mary
M.A. Molecular Biology, Princeton University
Ph.D. Molecular Biology, Princeton University
Postdoctoral research, Biochemistry and Molecular Biology, Michigan State University
Courses Taught
Concepts of Biology: Genes, Genomics, and Society (BIO 118)
Principles of Biology III: Cells and Molecules (BIO 152)
Biochemistry (BIO 220)
Genomes and Gene Evolution (BIO 385), with Dr. Bruce Wightman
Foods, Broods, and Moods: The Impact of Genetics on Society (FYS 236)
Research Interests
My scientific interests focus on
the regulation of gene function; in particular, I am interested in how
factors such as packaging of DNA into chromatin and DNA methylation may
affect gene expression in eukaryotic organisms. My current research
investigates the biological roles of proteins known to covalently
modify chromatin structure. Disruption of the corresponding genes in
the model plant Arabidopsis thaliana results in dramatic
effects on growth and development. Further research studying these
factors and chromatin modification in general will be carried out using
a variety of approaches, allowing students to develop projects in the
areas of molecular biology & biochemistry, genetics, and
developmental biology.
Publications
Hark, A.T. 2008. Crossing over: An
undergraduate service learning project that connects to biotechnology
education in secondary schools. Biochemistry and Molecular Biology Education 36, 159-165.
Hark, A.T. and S.J. Triezenberg. 2001. Chromatin and transcription: merging package and process. Cell 105, 321-323 (book review).
Hark, A.T.*, C.S. Schoenherr*, D.J. Katz, R.S.
Ingram, J.M. Levorse, and S.M. Tilghman. 2000. CTCF mediates
methylation-sensitive enhancer blocking activity at the H19/Igf2 locus. Nature, 405, 486-489.
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