Education
B.S. Biology, summa cum laude, College of William and Mary
M.A. Molecular Biology, Princeton University
Ph.D. Molecular Biology, Princeton University
Postdoctoral research, Biochemistry and Molecular Biology, Michigan State University
Courses Taught
Concepts of Biology: Genes, Genomics, and Society (BIO 118)
Principles of Biology III: Cells and Molecules (BIO 152)
Biochemistry (BIO 220)
Research Interests
My scientific interests focus on the regulation of gene function; in particular, I am interested in how factors such as packaging of DNA into chromatin and DNA methylation may affect gene expression in eukaryotic organisms. My current research investigates the biological roles of proteins known to covalently modify chromatin structure. Disruption of the corresponding genes in the model plant Arabidopsis thaliana results in dramatic effects on growth and development. Further research studying these factors and chromatin modification in general will be carried out using a variety of approaches, allowing students to develop projects in the areas of molecular biology & biochemistry, genetics, and developmental biology.
Publications
Hark, A.T. and S.J. Triezenberg. 2001. Chromatin and transcription: merging package and process. Cell105, 321-323 (book review).
Hark, A.T.*, C.S. Schoenherr*, D.J. Katz, R.S. Ingram, J.M. Levorse, and S.M. Tilghman. 2000. CTCF mediates methylation-sensitive enhancer blocking activity at the H19/Igf2 locus. Nature, 405, 486-489.
Hark, A.T. and S.M. Tilghman. 1998. Chromatin conformation of the H19 epigenetic mark. Human Molecular Genetics, 7, 1979-1985. |
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