Amy Hark

Professor of Biology
Co-director of Biochemistry

 Visit Amy Hark's website

New Science Building 225

 484-664-3747
 amyhark@muhlenberg.edu

 

Education

B.S. Biology, summa cum laude, College of William and Mary
M.A. Molecular Biology, Princeton University
Ph.D. Molecular Biology, Princeton University
Postdoctoral research, Biochemistry and Molecular Biology, Michigan State University

Courses Taught
Concepts of Biology: Genes, Genomics, and Society (BIO 118)
Wearing Our Genes: DNA and Determinism (BIO 283)
Principles of Biology III: Cells and Molecules (BIO 152)
Biochemistry (BIO 220)
Genomes and Gene Evolution (BIO 472)
Foods, Broods, and Moods: The Impact of Genetics on Society (FYS 236)

Research Interests
My scientific interests focus on the regulation of gene function; in particular, I am interested in how factors such as packaging of DNA into chromatin and organization of genes within genomes  may affect gene expression in eukaryotic organisms. Students in my lab are currently engaged in a comparative genomics project that uses in silico (computer-based) analysis to annotate genes in Drosophila species, a collaborative effort of the Genomics Education Partnership (thegep.org). Past and future projects include studying the role of chromatin structure and other epigenetic mechanisms  in the model plant Arabidopsis thaliana and DNA barcoding work in collaboration with Dr. Lara Goudsouzian at DeSales University

Recent Publications   *denotes undergraduate co-author

Lopatto, D., A. Rosenwald, J. DiAngelo, A. Hark…and S.C.R. Elgin (~100 authors). 2020. Facilitating Growth through Frustration: Using Genomics Research in a Course-based Undergraduate Research Experience. Journal of Microbiology & Biology Education 21(1). doi:10.1128/jmbe.v21i1.2005

Wagner, M.*, J. Hanna*, and A.T. Hark. 2020. Making Connections: The role of dystrophin in Duchenne Muscular Dystrophy. National Center for Case Study Teaching in Science. https://sciencecases.lib.buffalo.edu/collection/detail.html?case_id=1104&id=1104

Hark, A.T. and E.R. McCain. 2019. The Histone Acetyltransferase GCN5 and the Transcriptional Coactivator ADA2b Affect Trichome Initiation in Arabidopsis thaliana. microPublication Biology. https://doi.org/10.17912/micropub.biology.000176

Kotak, J.*, A. Kendig*, K. Cann*, J. Shaffer*, A.T. Hark, and E.R. McCain. 2019. Disruption of the Histone Acetyltransferase GCN5 and the Transcriptional Coactivator ADA2b Affect Trichome Density in Arabidopsis thaliana. microPublication Biology. https://doi.org/10.17912/micropub.biology.000174

Trachtman, N.*, P. Sockler*, H. Caiola*, E.R. McCain, and A.T. Hark. 2019. Expression of the DELLA Repressor GAI and its Regulators SPY and SEC are Impacted by Disruption of Chromatin Modifiers. microPublication Biology. https://doi.org/10.17912/micropub.biology.000175

Kotak, J.*, M. Saisana, V. Gegas, N. Pechlivani, A. Kaldis, P. Papoutsoglou, A. Makris, M. Sheikh*, J. Burns*, A.L. Kendig*, C.E. Kuschner*, G. Whitney*, H. Caiola*, J.H. Doonan, K.E. Vlachonasios, E.R. McCain, and A.T. Hark. 2018. Transcriptional coactivators affect leaf development and trichome morphogenesis in Arabidopsis. Planta 248: 613-628

Hark, A.T. 2017. Understanding Protein Domains: A Modular Approach. CourseSource. https://doi.org/10.24918/cs.2017.21 (Accessed December 6, 2017)

Farber, G. A. and A.T. Hark. 2017. Cut-It-Out: CRISPR-Cas9 case study. National Center for Case Study Teaching in Science. http://sciencecases.lib.buffalo.edu/cs/files/crispr.pdf (Accessed June 20, 2017)

Leung, W.…A.T. Hark,… M. Scheuerman*,… S.C.R. Elgin (276 authors). 2017. Retrotransposons are the major contributors to the expansion of the Drosophila ananassae Muller F element. G3: Genes, Genomes, Genetics7: 2439-2460.

Leung, W….A.T.Hark, A. Bertolet*, C.E. Kuschner*, K. Parry*, M. Quach*, L. Shantzer*…and S.C.R. Elgin (>1000 authors). 2015. Drosophila Muller F elements maintain a distinct set of genomic properties over 40 million years of evolution. G3: Genes, Genomes, Genetics 5: 719-740.